HOPping to the vacuole: Autophagosome and late endosomes combine to control plant autophagosome degradation
Résumé
Autophagy is an essential intracellular degradation pathway in eukaryotes that involves the engulfment of cellular material into double-membrane structures called autophagosomes.1 In plants autophagy is induced by a diverse array of abiotic and biotic stresses, including nutrient starvation, pathogens, and osmotic stress.2 The general mechanisms for autophagosome formation in eukaryotes are largely conserved. Autophagosomes are formed through the assembly of a crescent-shaped isolation membrane, named the phagophore, which expands around cargo and subsequently closes. Following this, the autophagosomes fuse with the lytic vacuole. The mechanisms by which autophagosomes are transported to the vacuole and fuse with the tonoplast to deliver cargo for degradation is only beginning to be understood in plant cells. Here, Jiang et al. provide substantial biochemical, genetic, and microscopic evidence that VPS41 facilitates a distinct autophagosome-to-vacuole fusion pathway that is induced upon a wide variety of stresses.
Domaines
Sciences du Vivant [q-bio]Origine | Fichiers produits par l'(les) auteur(s) |
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